This segment collects any info citations, information availability statements, or supplementary materials bundled in the following paragraphs.Compound seven was discovered like a potent (IC50 = 14 nM), selective, and orally bioavailable (F = 70% in mouse) inhibitor of protein kinase B/Akt. While promising efficacy was noticed in vivo, this compound

The mechanism for the C–N bond formation within the copper catalysed reaction of arylboronic acids with diazadicarboxylates has become proposed by Uemura and Chatani.TFA was an appropriate acid to the cyclization stage to give the corresponding products 4a–d, j, k in the reaction of boronic acid 1a with hydrazine dicarboxylates 7a–f (Table si

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